Flow Cytometric Analysis of Micronucleus Induction in Mice by Internal Exposure to137Cs at Very Low Dose Rates
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 67 (1) , 29-36
- https://doi.org/10.1080/09553009514550041
Abstract
Internal radiation from 137Cs, intraperitoneally injected into mice, induced chromosome damage seen as micronuclei in erythrocytes of peripheral blood harvested 72 h after injection and analysed with flow cytometry. The retention of injected 137Cs activity was determined and the absorbed doses obtained from the beta-radiation of 137Cs were calculated for the whole bodies and bone marrow of the treated mice. The absorbed doses during the most relevant period for micronucleus induction were 2.7-18.3 mGy per day. The dose to the bone marrow during the same period was calculated to be 6-44 mGy per day. A linear dose response relationship was found.Keywords
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