Cephalosporin‐induced immune neutropenia

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Abstract
Neutropenia is an occassional complication of treatment with cephalosporin antibiotics. This report describes 2 patients who had neutropenia while receiving high doses of cephalosporins. The neutrophil counts returned to normal after stopping the drug, and cephalosporin-dependent neutrophil antibodies were demonstrated in both cases, using the granulocyte immunofluorescence test. In 1 patient, the immune neutropenia appeared to be due to a drug adsorption mechanism similar to penicillin-induced hemolytic anemia, while an immune complex mechanism may have been involved in the 2nd patient.