Cephaloridine. Studies of therapeutic activity and untoward effects

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Abstract
Seventy-six patients with suspected or proved bacterial infections were treated with cephaloridine. Of 67 in whom cephaloridine-sensitive organisms were responsible for disease, 58(86%) showed excellent clinical and bacteriological responses. Many of these individuals had potentially fatal infections; 12 had staphylococcal bacteremia and 5 had bacteremia due to other organisms. Adverse reactions occurred in 27 (35%) of the 76 patients. Minor reactions included allergic phenomena, phlebitis at the site of infusion, nausea and vomiting, and transient leukopenia. More serious reactions occurring in 11 patients were superinfections in 3 patients, anaphylaxis in 2, and reversible renal injury in 5; one developed a Coombs'' positive hemolytic anemia and profound renal failure. This agent may be responsible for hemolytic anemia and kidney damage in man.