Cleavage of Leishmania Mini-exon Sequence by Oligonucleotides Conjugated to a Dimidazole Construction

1 July 1997

journal article
research article
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 16 (7-9) , 1721-1725
https://doi.org/10.1080/07328319708006263

Abstract

RNA sequences derived from the Leishmania amazonensis mini-exon and pre-mini-exon sequences have been targeted with complementary oligonucleotides bearing a diimidazole construction mimicking active center of ribonuclease A. The conjugates were shown to cleave the target RNAs at specific positions.

Keywords

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