STUDIES OF 17-HYDR0XYC0RTIC0STER0IDS. X. URINARY EXCRETION OF 17-HYDROXYCORTICOSTEROIDS IN PATIENTS WITH RHEUMATIC FEVER*

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Abstract
Urinary 17-hydroxycorticosteroid (17-OHCS) excretion was 5.6 [plus or minus] 0.65 mg/day for normal adult males and 2.2 [plus or minus] 0.27 mg/day for control children. In children with rheumatic fever, even in the very acute phase of activity, these excretion values were not different from those of the control children. The 17-OHCS urinary excretion values were determined in these children during and after periods of therapy with ACTH-gel, cortisone, or salicylates. The steroid excretion values increased during hormone therapy, roughly proportional to the dose of hormone given. However, there was considerable individual variation and even considerable variation on serial determinations in the same patient and on the same dose of hormone. Excretion values in the post-cortisone therapy period (2-7 days post-therapy) were depressed significantly. In contrast to the increased urinary 17-OHCS excretions during hormone therapy, the urinary excretions of these steroids during salicylate therapy were significantly lower than those observed during the control periods.