Tissue Levels of Bone Resorptive Cytokines in Periodontal Disease

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Abstract
The levels of 3 bone resorptive cytokines, interleukin 1α (IL‐1α), IL‐1β, and tumor necrosis factor α (TNFα), were assessed in tissues from sites of periodontal disease. As determined by ELISA of tissue extracts, IL‐1β and TNFα were detected in all diseased sites, whereas IL‐1α was present in 8/22 sites. IL‐1β was present in highest concentration (mean ± SEM: 11,695 ± 2,888 pg/ml; 672 pM), followed by TNFα (434 ± 135 pg/ml; 26 pM), and IL‐1α (342 ± 160 pg/ml; 20 pM). The levels of all 3 mediators were significantly lower in clinically healthy tissues. There was a highly significant correlation between levels of IL‐1β and TNFα (rs = 0.61, P J Periodontol 1991; 62:504–509.