Expression and rearrangement of the ROS1 gene in human glioblastoma cells.
Open Access
- 1 December 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (24) , 9270-9274
- https://doi.org/10.1073/pnas.84.24.9270
Abstract
The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, we found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and not to be expressed at all, or expressed at very low levels, in the remaining cell lines. The ROS1 gene was present in normal copy numbers in all cell lines that expressed the gene. However, in one particular glioblastoma line, we detected a potentially activating maturation at the ROS1 locus.This publication has 18 references indexed in Scilit:
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