The human c-ros gene (ROS) is located at chromosome region 6q16----6q22.
- 1 September 1986
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (17) , 6568-6572
- https://doi.org/10.1073/pnas.83.17.6568
Abstract
The human homolog, c-ros, of the transforming gene, v-ros, of the avian sarcoma virus, UR2, has been isolated from a human genomic library. A single-copy fragment from the human c-ros genomic clone has been used to map the human c-ros homolog (ROS) to human chromosome region 6q16----6q22 by somatic cell hybrid analysis and chromosomal in situ hybridization. Thus, the c-ros gene joins the c-myb oncogene, which is distal to the c-ros gene on the long arm of human chromosome 6, as a candidate for involvement in chromosome 6q deletions and rearrangements seen in various malignancies.Keywords
This publication has 56 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Sublocalization of c-myb to 6q21→q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangementsCytogenetic and Genome Research, 1986
- The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1Cell, 1985
- Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesNature, 1985
- Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsNature, 1984
- Chromosomal sublocalization of human c-myb and c-fes cellular onc genesNature, 1983
- A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming proteinCell, 1982
- Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene productCell, 1978
- Expression of HLA‐A, but not of HLA‐B, in mouse‐human somatic cell hybrids carrying the region p21→pter of human chromosome 6European Journal of Immunology, 1978
- Characteristic chromosomal abnormalities in biopsies and lymphoid‐cell lines from patients with burkitt and non‐burkitt lymphomasInternational Journal of Cancer, 1976