Hematopoietic Reconstitution in a Patient with Fanconi's Anemia by Means of Umbilical-Cord Blood from an HLA-Identical Sibling

Publisher Website
Google Scholar
Abstract
THE clinical manifestations of Fanconi's anemia, an autosomal recessive disorder, include progressive pancytopenia, a predisposition to neoplasia, and nonhematopoietic developmental anomalies.1 2 3 Hypersensitivity to the clastogenic effect of DNA–cross-linking agents such as diepoxybutane acts as a diagnostic indicator of the genotype of Fanconi's anemia, both prenatally and postnatally.3 4 5 6 Prenatal HLA typing has made it possible to ascertain whether a fetus is HLA-identical to an affected sibling.7 We report here on hematopoietic reconstitution in a boy with severe Fanconi's anemia who received cryopreserved umbilical-cord blood from a sister shown by prenatal testing to be unaffected by the disorder, to have a normal . . .