It Is Possible to Stimulate Intestinal Calcium Absorption during Experimental Chronic Renal Failure

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Abstract
To explore the assumption on the functional inadequacy of renal alternative vitamin D synthesis during chronic renal failure, 50 subtotally-nephrectomized rats were treated with dihydrotachysterol, androgens, estrogens or androgens + estrogens. Fractional duodenal Ca absorption and Ca-binding protein content of intestinal mucosa were determined. Fractional duodenal Ca absorption was significantly decreased in uremic rats (6.61 .+-. 1.64%). Dihydrotachysterol or androgen + estrogen administration lead to 3-fold increase in fractional duodenal Ca absorption, accompanied by the enhancement in Ca-binding protein content of mucosal layer. It is possible to stimulate intestinal Ca absorption during experimental chronic renal failure, probably via the rehabilitation of 1,25(OH)2D3 production.