ALPHA-METHYLDOPAMINE, A KEY INTERMEDIATE IN THE METABOLIC DISPOSITION OF 3,4-METHYLENEDIOXYAMPHETAMINE INVIVO IN DOG AND MONKEY

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 6  (6) , 623-630
Abstract
Metabolites of 3,4-methylenedioxyamphetamine [one of the hallucinogenic alkoxyphenylisopropylamines] in the urine of dogs and monkeys were separated by GLC as their trifluoroacetyl and/or n-butyl ether derivatives and identified by comparison of the chromatographic and mass spectrometric behavior of these derivatives with those of synthetic compounds. The metabolites identified in dog and monkey urine were .alpha.-methyldopamine, 3-O-methyl-.alpha.-methyldopamine, and 3,4-dihydroxybenzyl methyl ketone. The monkey urine also contained 3,4-methylenedioxybenzyl methyl ketone and 3,4-methylenedioxybenzoic acid present as a glucuronide and/or sulfate conjugate, whereas the dog urine had 3-methoxy-4-hydroxybenzoic acid present as a conjugate other than glucuronide and sulfate. The phenolic metabolites in both species were present free and as glucuronide and/or sulfate conjugates.