Determination of a Relationship Between Force-Displacement and Force-Time Compression Curves
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 16 (2) , 201-229
- https://doi.org/10.3109/03639049009114881
Abstract
A series of experiments were conducted to evaluate and compare force-displacement and force-time compression curves. A Stokes B-2 sixteen station rotary tablet press was instrumented with piezoelectric transducers to monitor compression and ejection forces (in addition to punch proximity) and interfaced with a microcomputer. Processing and material variables were examined for their effects on the direct parameters (ie. height and area) and derived parameters (ie. area:height ratio and maximum s1ope:height ratio) of the force-time compression curve. Upper punch displacement was estimated and force-displacement curves were plotted. The force-time curve was then divided into three segments pertaining to the three stages of upper punch movement: compression, relaxation, and decompression. The “relaxation” stage was defined as the portion of the compression force-time curve corresponding to the interval when the upper punch displacement was held constant. The total, net and elastic works of compaction were calculated and their relationships with the areas of the individual phases of the force-time compression curve were examined. It appears that the area under the cornpression force-time curve can be related satisfactorily to the work of compaction.This publication has 4 references indexed in Scilit:
- Technical correspondenceCommunications of the ACM, 1986
- Theoretical estimation of punch velocities and displacements of single-punch and rotary tablet machinesJournal of Pharmacy and Pharmacology, 1984
- Viscoelastic Stress/Strain Behavior of Pharmaceutical Tablets: Analysis during Unloading and Postcompression PeriodsJournal of Pharmaceutical Sciences, 1981
- Physical Processes of TabletingJournal of Pharmaceutical Sciences, 1977