POLYOSTOTIC FIBROUS DYSPLASIA ASSOCIATED WITH HYPERTHYROIDISM

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Abstract
POLYOSTOTIC fibrous dysplasia, when associated with endocrinopathies and pigmentation of the skin, has been termed “Albright's syndrome” following the report in 1937 by Albright et al. (1). The most common endocrine dysfunction is precocious puberty in females. Less frequent but thought to be significantly related is the presence of hyperthyroidism. This report reviews all cases in the literature and presents 2 additional cases in which there was coexistence of hyperthyroidism and fibrous dysplasia. For detailed radiologic, pathologic and clinical features of this syndrome, the reader is referred to the recent excellent reviews by Furst and Shapiro (2), Albright (3, 4), Dockerty et al. (5), Lichtenstein and Jaffe (6) and Gorham et al. (7). In Table 1 only those cases in which the diagnosis of hyperthyroidism is unequivocal are included. The cases of Horowitz and Cantarow (12), Caldwell and Broderick (13), Dockerty et al. (5), Gaupp (14), Summerfeldt and Brown (15) and Thannhauser (16) (which are not included in Table 1) contain features such as moderately elevated basal metabolism and exophthalmos, which suggest that mild hyperthyroidism may have been present. In none of these cases, however, were the clinical signs or laboratory tests conclusively diagnostic of hyperthyroidism.