PULMONARY PLATELET DEPOSITION ACCOMPANYING ACUTE OLEIC-ACID-INDUCED PULMONARY INJURY

Abstract
Rabbits were injected with 111In platelets and then received an infusion of oleic acid (0.125 g/kg) or normal saline. One hour after receiving oleic acid, the animals developed hypoxemia, thrombocytopenia and an edematous hemorrhagic lung injury. The number of platelets in the lung was increased compared to that in control rabbits, showing that pulmonary platelet deposition accompanies oleic-acid-induced lung injury.