Sequence homology and structural comparison between the chromosomal human α1-antitrypsin and chicken ovalbumin genes
- 1 June 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 297 (5868) , 655-659
- https://doi.org/10.1038/297655a0
Abstract
The human chromosomal .alpha.1-antitrypsin gene was cloned. This gene is approximately 5 kilobase pairs long and contains 3 intervening sequences in the peptide-coding region. DNA sequences coding for the amino and carboxyl termini of .alpha.1-antitrypsin were identified. Human .alpha.1-antitrypsin and chicken ovalbumin show significant sequence homology and belong to a common protein superfamily. Yet the number, position and size of intervening sequences reveal that the 2 genes are dissimilar.Keywords
This publication has 51 references indexed in Scilit:
- Cloning and sequence of cDNA coding for alpha 1-antitrypsin.Proceedings of the National Academy of Sciences, 1981
- Induction of α1-antitrypsin mRNA and cloning of its cDNABiochemical and Biophysical Research Communications, 1981
- The role of elastases in the development of emphysemaLung, 1978
- The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNACell, 1978
- Human lysosomal elastase. Catalytic and immunological propertiesBiochemical Journal, 1976
- Fluorescent Antibody Studies of Alpha-1-Antitrypsin in Adult Human LungAmerican Journal of Clinical Pathology, 1975
- Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.Journal of Clinical Investigation, 1975
- A New Method for Determination of Alpha-1-antitrypsin Phenotypes Using Isoelectric Focusing on Polyacrylamide Gel SlabsAmerican Journal of Clinical Pathology, 1974
- The Neutral Proteases of Human GranulocytesEuropean Journal of Biochemistry, 1973
- The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin DeficiencyScandinavian Journal of Clinical and Laboratory Investigation, 1963