Chemo-enzymic synthesis of guanosine 5′-diphosphomannose (GDP-mannose) and selected analogues
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 23,p. 3017-3022
- https://doi.org/10.1039/p19930003017
Abstract
Guanosine 5′-diphosphomannose (GDP-mannose, 1) has been prepared via two routes from α-D-mannose 1-phosphate 5. The non-enzymic route involves coupling of the phosphate 5 to guanosine 5′-monophosphate dibutyl phosphinothioc anhydride (GMP-anhydride 11) to give compound 1 in 40% yield. The enzymic routes require coupling of compound 5 with guanosine 5′-triphosphate (GTP) catalysed by GDP-mannose pyrophosphorylase (37% yield).Keywords
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