The Influence of Aerosol Size on Retention and Translocation of 241Am Following Inhalation of 241AmO2 by Beagles

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Abstract
Beagle dogs received a single inhalation exposure to a monodisperse or a polydisperse aerosol of 241AmO2 to determine the radiation dose to internal organs. Monodisperse aerosols (0.75, 1.5 and 3.0 .mu.m activity median aerodynamic diameter) and 1 polydisperse aerosol (1.8 .mu.m activity median aerodynamic diameter) were used to assess the role of particle size in clearance of 241AmO2 from the lung and the rate of translocation of 241Am to other tissues. Dogs were sacrificed in groups of 2 or 3 at 8, 32, 64, 128, 256, 365 and 730 days after exposure. The clearance rate of 241Am from lung was particle size-dependent; this resulted in an increased radiation dose to lung at 2 yr by 70% as particle size increased from 0.75 to 3.0 .mu.m aerodynamic diameter. The radiation dose to liver and skeleton decreased by 20 and 35%, respectively, as particle size increased from 0.75 to 3.0 .mu.m. When the radiation doses absorbed by lung, liver and skeleton were compared to those predicted by the ICRP [International Commission on Radiological Protection] 30 model, differences were noted.

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