INBRED MOUSE STRAIN RESISTANCE TO MYCOBACTERIUM-LEPRAEMURIUM FOLLOWS THE ITY LSH PATTERN

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (1) , 149-156
Abstract
Inbred mouse strains and their F1 hybrids infected i.v. with M. lepraemurium showed different mean survival times (MST). BALB/c and C57BL mice were particularly susceptible; C3H, CBA and DBA/2 mice were relatively resistant. Resistance as judged by MST was dominant in the F1 hybrids. A similar ranking order was obtained by comparing the doubling time of the bacillus in the bone marrow, the increase in spleen weight between 4 and 12 wk after infection and the pathology of the liver during infection. The general pattern suggests that mouse resistance to M. lepraemurium is, at least is part, controlled by a gene with the same strain distribution as the genes for resistance to Salmonella typhimurium (Ityr) and Leishmania donovani (Lshr) and the gene controlling resistance to M. bovis BCG (Bcg). Ity, Lsh and Bcg are all on chromosome 1, suggesting a center controlling reactions to intracellular infections.