Long-Term Monitoring of Tricyclic Antidepressant Plasma Concentrations

Publisher Website
Google Scholar
Abstract
Plasma levels of antidepressant drugs (imipramine, clomipramine, maprotiline, amitriptyline) were measured in 17 depressed patients at, roughly, monthly intervals over follow-up periods of 3-26 mo. Good results in 7 were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome. Such fluctuations were probably from poor compliance or drug interaction from self-medication. Severe side effects and cardiotoxicity were associated with high levels.

This publication has 16 references indexed in Scilit: