MODEL FOR LOCAL ACCUMULATION OF BONE IMAGING RADIOPHARMACEUTICALS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (11) , 1106-1111
Abstract
A simple model, having phenomenological parameters as variables, is developed for predicting local radioactive tracer accumulation in bone. Blood delivering tracer to 1 g of bone is treated as a compartment separate from the remainder of the circulation in order to observe the effects produced by variations in both bone blood flow and barrier permeability. Kinetic curves derived by analog computer were obtained for normal and perturbed values of the parameters for 18F and 47Ca in a segment of rabbit bone. Apparent confirmation of the predicted influence of decreased blood flow on 18F deposition was obtained by measuring bone uptake following constriction of the right femoral artery in 5 rabbits. Such models may prove useful in explaining variations in uptake for different agents, in selecting imaging times and in correlating uptake patterns with disease.

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