STRUCTURED EXPLORATORY DATA-ANALYSIS (SEDA) FOR DETERMINING MODE OF INHERITANCE OF QUANTITATIVE TRAITS .2. SIMULATION STUDIES ON THE EFFECT OF ASCERTAINING FAMILIES THROUGH HIGH-VALUED PROBANDS
- 1 January 1981
- journal article
- research article
- Vol. 33 (2) , 282-292
Abstract
An understanding of the effect of selecting families through a hind-valued proband on the major gene index (MGI), the offspring between parents function (OBP) and the pairwise midparental correlation coefficient (MPCC) is developed. The interpretations of these statistics must be carefully modified to adjust for the biases created by the selection criteria. Computer simulations are used to examine sporadic, multifactorial and major gene models under moderate (85%) and extreme (95%) proband selection. Additional insights may be acquired into the nature of mode of inheritance by comparing and contrasting selected and unselected populations.This publication has 8 references indexed in Scilit:
- STRUCTURED EXPLORATORY DATA-ANALYSIS (SEDA) FOR DETERMINING MODE OF INHERITANCE OF QUANTITATIVE TRAITS .1. SIMULATION STUDIES ON THE EFFECT OF BACKGROUND DISTRIBUTIONS1981
- Aggregation of coronary risk factors in families of men with fatal and non-fatal coronary heart disease.Heart, 1979
- Familial aggregation of coronary heart disease in a high incidence area (North Karelia, Finland).Heart, 1979
- SAMPLING CONSIDERATIONS IN THE GATHERING AND ANALYSIS OF PEDIGREE DATA1979
- Detection of rare major genes in lipid levelsHuman Genetics, 1979
- Ascertainment in the sequential sampling of pedigreesClinical Genetics, 1977
- Coronary artery disease and its risk factors in families of young men with angina pectoris and in controls.Heart, 1977
- INHERITANCE OF LOW ERYTHROCYTE CATECHOL-O-METHYLTRANSFERASE ACTIVITY IN MAN1977