The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites.
Open Access
- 1 September 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (9) , 4079-4082
- https://doi.org/10.1128/mcb.9.9.4079
Abstract
The promoter region of the mouse thymidylate synthase gene was analyzed by deletion and site-directed mutagenesis. Elimination of an upstream Sp1 element reduced expression threefold, whereas elimination of an adenovirus upstream stimulatory factor element had little effect. All of the upstream elements that are essential for promoter activity are located within 22 nucleotides of the first transcriptional initiation site.This publication has 26 references indexed in Scilit:
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