NITROGEN BALANCE AND PLASMA PROTEIN REGENERATION IN HYPOPROTEINEMIC DOGS

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Abstract
Plasma protein regeneration was studied in hypoproteinemic dogs which were depleted until the plasma protein conc, was relatively constant between 4.0 and 4.5 g./ 100 ml. The dogs received a protein-free diet during the process of depletion, plasmapheresis being performed several days in order to hasten depletion. The depleted animals were fed protein for 5 days and then returned to the protein-free diet until the plasma protein cone, had returned to the former depleted state. Plasma proteins in g. % were plotted against days and the area under the curve showing the increase above the depleted conc, was taken as a measure of the amt. of regeneration. N balances were detd. before protein depletion and in the depleted state before, during and after protein feeding. Protein depleted dogs snowed a marked decrease in urinary N excretion from the control periods of the dogs in the undepleted state. When these protein depleted dogs received dietary protein the type of plasma proteins regenerated varied depending on the source of protein. Bovine serum protein fed orally caused regeneration of albumin, casein favored both albumin and globulin regeneration and Amigen, administered intravenously, stimulated globulin formation. The regeneration of total plasma protein increased with increasing positive N balance in hypoproteinemic dogs. The amt. of regeneration, seemed to be dependent upon the magnitude of the positive N balance. The biologic values of bovine serum protein and casein were higher than in normal animals, being 0.98 and 0.97 respectively in the hypoproteinemic dogs.

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