Normalization of Serum Cortisol Concentration With Opioid Treatment of Severe Chronic Pain
- 1 June 2002
- journal article
- Published by Oxford University Press (OUP) in Pain Medicine
- Vol. 3 (2) , 132-134
- https://doi.org/10.1046/j.1526-4637.2002.02019.x
Abstract
Serum cortisol concentrations may be altered in severe, chronic pain due to excess stimulation of the hypothalamic-pituitary-adrenal axis. Among 40 consecutive patients with severe, chronic pain 26 (65.0%) demonstrated abnormal serum cortisol concentration. After 90 days of treatment, only 7 (17.5%; p<0.01) continued to show abnormal serum cortisol concentration indicating that serum cortisol and other serologic abnormalities may serve as biologic markers of severe, chronic pain.Keywords
This publication has 10 references indexed in Scilit:
- Fluoride Uptake in Human Teeth from Fluoride–Releasing Restorative Material in vivo and in vitro: Two–Dimensional Mapping by EPMA–WDXCaries Research, 2001
- Suffering: the contributions of persistent painThe Lancet, 1999
- Abnormal Adrenal Gland Metabolism in Opioid Addicts: Implications for Clinical TreatmentJournal of Psychoactive Drugs, 1991
- Pain can killPain, 1991
- Blood-Brain Barrier: Endogenous Modulation by Adrenal-Cortical FunctionScience, 1985
- Induction of the Intermediate Pituitary by Stress: Synthesis and Release of a Nonopioid Form of β-EndorphinScience, 1985
- Cosyntropin (ACTH alpha 1-24) stimulation test in depressed patients and healthy subjectsAmerican Journal of Psychiatry, 1983
- OPIATE MODULATION OF THE PITUITARY‐ADRENAL AXIS: EFFECTS OF STRESS AND CIRCADIAN RHYTHMClinical Endocrinology, 1982
- Biochemical changes associated with intractable pain.BMJ, 1978
- The effect of pain on the diurnal pattern of plasma corticoid levelsNeurology, 1964