MULTIPOTENTIAL CARCINOGENICITY OF THE FRIED FOOD MUTAGEN 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE IN RATS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 76  (7) , 570-576
Abstract
The carcinogenicity of the mutagenic compound 2-amino-3-methylimidazo[4,5-f]-quinole (IQ), identified in fried and broiled foods, was investigated in female Sprague-Dawley rats. Administration by gavage of IQ (0.4 mmol/kg body wt) on a weekly regimen for 31 wk starting with 6-wk-old animals induced a high yield of multiple mammary gland carcinomas in a limited bioassay lasting a total of 52 wk. In a positive control group receiving 4-aminobiphenyl (4-AB), the expected carcinomas in the mammary gland developed. IQ, but not 4-AB, also yielded neoplasms in the ear duct and to a lesser degree, the liver, pancreas and urinary bladder. With IQ, a high incidence of preneoplastic lesions in the pancreas was observed. Vehicle and untreated controls did not have any lesions. These findings demonstrate that IQ is a powerful multipotent carcinogen in the rat.

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