The effect of heat, pH and some buffer materials on the hydrolytic degradation of sulphacetamide in aqueous solution
- 1 April 1971
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 23 (4) , 252-261
- https://doi.org/10.1111/j.2042-7158.1971.tb08654.x
Abstract
The hydrolytic degradation of sulphacetamide has been investigated under anoxic conditions over a wide range of pH values and at different temperatures. The sole breakdown product is sulphanilamide. The reaction is essentially independent of pH (measured at 25°) over the range 5 to 11, but is subject to catalysis by buffer constituents. Below pH 4 specific hydrogen ion catalysis occurs. Calculation of activation parameters leads to the conclusion that sulphacetamide solutions can be satisfactorily autoclaved provided they are not subsequently refrigerated.Keywords
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