Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.
Open Access
- 1 July 1985
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 162 (1) , 363-368
- https://doi.org/10.1084/jem.162.1.363
Abstract
Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.Keywords
This publication has 17 references indexed in Scilit:
- Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.The Journal of Experimental Medicine, 1984
- Molecular cloning and expression of cDNAs for the human interleukin-2 receptorNature, 1984
- Characterization of human interleukin 2 receptor (Tac antigen) in normal and leukemic T cells: co-expression of normal and aberrant receptors on Hut-102 cells.The Journal of Immunology, 1984
- Characterization of the human receptor for T-cell growth factor.Proceedings of the National Academy of Sciences, 1983
- Purification and partial sequence analysis of human T-cell growth factor.Proceedings of the National Academy of Sciences, 1983
- Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen.The Journal of Experimental Medicine, 1983
- A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptorNature, 1982
- T cell growth factor receptors. Quantitation, specificity, and biological relevanceThe Journal of Experimental Medicine, 1981
- A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.The Journal of Immunology, 1981
- T‐Cell Growth FactorImmunological Reviews, 1980