Effect of Guar Gum and Pectin N. F. on Serum and Liver Lipids Of Cholesterol Fed Rats

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Abstract
The oral adminis-tration to rats of guar gum and pectin N. F. at levels up to 10% of a semi-purified casein-sucrose basal diet for a period of 28 days greatly reduced the elevations in liver sterol and total liver lipids produced by the feeding of 1% cholesterol. Similar results were also obtained in rats when a powdered Purina Lab Chow diet was employed; however, the extent of liver lipid deposition in the cholesterol-fed controls was considerably less than that observed with the casein-sucrose diet. Guar gum was considerably more active than pectin N. F., which con-firms the results of similar experiments previously carried out with chickens.