Effects of fenfluramine on the adrenergic system

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Abstract
The influence of fenfluramine on sympathetic transmission has been examined in various intact and isolated preparations. Fenfluramine both facilitated and inhibited the responses elicited by the sympathetic stimulation according to the dose administered and the preparation used. Fenfluramine, to a lesser extent than amphetamine, antagonized, in some preparations, the neuron blocking action of guanethidine. Fenfluramine did not antagonize the sympathomimetic effects elicited by amphetamine in the isolated atria and the isolated vas deferens unless very high concentrations of both drugs were used.