Endogenous prostaglandins in peptic ulcer disease.
Open Access
- 1 May 1979
- Vol. 20 (5) , 394-399
- https://doi.org/10.1136/gut.20.5.394
Abstract
Plasma concentrations of prostaglandins E and F have been measured by radioimmunoassay in patients undergoing diagnostic upper intestinal endoscopy. The results fail to support a previously reported deficiency of plasma PGE in duodenal ulcer patients. Plasma prostaglandin concentrations failed to correlate with the parameters of gastric secretion studied; and were unaffected by histamine H2-receptor blockade or the activity of duodenal ulceration. During combined pentagastrin and insulin secretory studies there was a significant correlation between the outputs of PGE and acid into gastric juice.Keywords
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