A postulated role for microRNA in cellular differentiation
- 1 June 2005
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 19 (8) , 875-879
- https://doi.org/10.1096/fj.04-3609hyp
Abstract
Over the past two decades a variety of mechanisms regulating cellular differentiation have been uncovered. These include signaling by morphogens or membrane-associated ligands and asymmetric segregation of cytoplasmic components. Most of these processes are driven by protein coding genes. Here I describe another possible cellular differentiation mechanism that involves asymmetric segregation of microRNAs, a group of recently discovered non-protein coding genes that have been shown to be involved in differentiation.—Bentwich, I. A postulated role for microRNA in cellular differentiation.Keywords
This publication has 37 references indexed in Scilit:
- MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissuesGenome Research, 2004
- MicroRNAs Modulate Hematopoietic Lineage DifferentiationScience, 2004
- MicroRNAsCell, 2004
- The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative GenomicsPLoS Biology, 2003
- MicroRNAs and Other Tiny Endogenous RNAs in C. elegansCurrent Biology, 2003
- The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat MetabolismCurrent Biology, 2003
- Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAsNature, 2002
- Prediction of Plant MicroRNA TargetsPublished by Elsevier ,2002
- An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegansScience, 2001
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993