THE EFFECT OF GLASS UPON THE ACTIVITY OF THE VARIOUS PLASMA CLOTTING FACTORS

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Abstract
Clotting behavior of platelet poor plasma exposed only to silicone surfaces was compared with that of plasma shaken with quartz glass powder. The effect of such glass activation upon the plasma clotting factors was measured in one-stage assays for antihemophilic A factor (anti-hemophilic globulin), antihemophilic B factor (PTC, Christmas factor), prothrombin, proconvertin and proaccelerin. Glass exposure increased antihemophilic B factor activity as old and proconvertin activity three-fold or more. No increase in antihemophilic A factor, prothrombin or proaccelerin activity was found. The increased antihemophilic B factor and proconvertin activity may be the result of the adsorption of a positively charged inhibitor onto the glass surface. The relation between the activation of proconvertin by glass and by thromboplastin plus Ca was examined. Proconvertin was defined as inactive proconvertin or active proconvertin and the difference between these activities and convertin was stressed.