GONADOTROPIC MODIFYING ACTION OF SERA OF ANIMALS TREATED WITH HYPOPHYSEAL EXTRACTS

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Abstract
THE PRESENT communication concludes our study of the effects produced by the chronic treatment of animals with implants or extracts of pituitaries of the same species. In our last publication on this topic (Katzman, Wade and Doisy, 1939), we reported that the sera obtained from sheep during 262 days of treatment with sheep pituitary extract continued to exhibit progonadotropic activity when tested with the same pituitary extract in immature female rats. In no instance during this period did this serum manifest inhibitory activity. Data were also presented showing that the sera of pigs treated for as long as 364 days with pig pituitary extract failed to exhibit consistent augmentatory or inhibitory properties. At this time we wish to present the data which we have obtained from a continuation of the above studies. The animals Sh 2 (ewe), Sh 3 (ram), Sh 4 (ram) and Pg 2 (sow)