An Overview of the Immune System with Specific Reference to Membrane Encapsulation and Islet Transplantation
- 1 November 2001
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 944 (1) , 226-239
- https://doi.org/10.1111/j.1749-6632.2001.tb03835.x
Abstract
Abstract: The concept of immunoisolation by use of a bioartificial membrane is discussed, concentrating on the immunological mechanisms that are likely to be operative in the light of recent information on the workings of the immune system. Special attention is given to the use of encapsulation for the purpose of treating autoimmune diabetes by implantation of xenogeneic islet tissue. It is argued that the term immunoisolation is misleading because the immune system is always activated by the indirect pathway of antigen presentation and that the term immunomodulation would be more appropriate.Keywords
This publication has 25 references indexed in Scilit:
- Regulatory T CellsCell, 2000
- What is the role of regulatory T cells in transplantation tolerance?Current Opinion in Immunology, 1999
- MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSINGAnnual Review of Immunology, 1998
- Anergic T cells effect linked suppressionEuropean Journal of Immunology, 1997
- Encapsulated islet cells: the role of direct and indirect presentation and the relevance to xenotransplantation and autoimmune recurrenceBritish Medical Bulletin, 1997
- Antigen processing and presentation in transplantationCurrent Opinion in Immunology, 1996
- Biophysical studies of T-cell receptors and their ligandsCurrent Opinion in Immunology, 1996
- Tolerance, Danger, and the Extended FamilyAnnual Review of Immunology, 1994
- Two types of mouse helper T-cell clone: Implications for immune regulationImmunology Today, 1987
- The Origin and Mechanism of the Allograft ReactionImmunological Reviews, 1977