Artificial Kidney. II. Construction and Operation of an Improved Continuous Dialyzer.

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Abstract
An improved type of continuous dialyzer designed for use as an artificial kidney and details for its operation and application is described. The dialyzer is composed of a variable number of units consisting of 2 identical longitudinally- grooved rubber pads between which are placed 2 sheets of cellophane. The units are constructed so as to be connected in series or in parallel, which enables alterations in the resistance of the "kidney" to the available blood flow and to insure blood flow in a uniform film in one direction and the dialyzing soln. flow in a counter-current direction. Dogs were given a lethal dose of uranyl nitrate. Treatment with 5 dialyses at 1- to 2-day intervals was successful in restoring blood urea N levels to normal. After the 5th dialysis, the animals were able to excrete urine and survived without further treatment.
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