O-methylation, the Principal Route of Metabolism of Epinephrine in Man
- 12 September 1958
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 128 (3324) , 593-594
- https://doi.org/10.1126/science.128.3324.593
Abstract
Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conLversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.Keywords
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