Hemodynamic responses to oxygen breathing in man

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Abstract
Hemodynamic responses to breathing 100% oxygen for an average of 30 min were studied in eight healthy male volunteers. Cardiac output and related determinations were performed with central injections of a radioactive indicator and calculated by the method of Stewart and Hamilton. Arterial blood gas analyses were performed in each phase of the study. Slight but statistically significant decreases in cardiac index and heart rate were observed during oxygen breathing. There was no change in the central blood volume, but a masked increase in pulmonary blood volume may have occurred. Statistically significant increases in peripheral vascular resistance, mean arterial pressure, and both systolic and diastolic arterial pressures occurred during oxygen breathing and persisted at least 40 min after oxygen was discontinued. Submitted on May 1, 1961