Mechanism of induction of Parkinson's disease by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chemical and electrochemical characterization of a geminal-dimethyl-blocked analog of a postulated toxic metabolite
- 1 April 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 108 (9) , 2464-2466
- https://doi.org/10.1021/ja00269a065
Abstract
No abstract availableThis publication has 27 references indexed in Scilit:
- Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidasePublished by Elsevier ,2004
- Conversion of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (mptp) and its 5‐methyl analog into pyridinium saltsHelvetica Chimica Acta, 1984
- Pargyline Prevents MPTP-Induced Parkinsonism in PrimatesScience, 1984
- The importance of the ‘4–5’ double bond for neurotoxicity in primates of the pyridine derivative MPTPNeuroscience Letters, 1984
- 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Destroys Dopamine Neurons in Explants of Rat Embryo MesencephalonScience, 1984
- 1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigraNeuroscience Letters, 1984
- Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in MiceScience, 1984
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983
- Synthesis, polarography and herbicidal activity of quaternary salts of 2‐(4‐pyridyl)‐1,3,5‐triazines, 5‐(4‐pyridyl)pyrimidine, 2‐(4‐pyridyl)pyrimidine and related compoundsJournal of Heterocyclic Chemistry, 1980
- Superoxide radical and the oxygen enhancement of the toxicity of paraquat in Escherichia coli.Journal of Biological Chemistry, 1978