Activation of T lymphocytes by the Fc portion of immunoglobulin
- 1 January 1980
- journal article
- research article
- Published by Wiley in Journal of Supramolecular Structure
- Vol. 13 (4) , 479-488
- https://doi.org/10.1002/jss.400130407
Abstract
T lymphocytes are stimulated to release T‐cell‐replacing factors in response to Fc fragments of human IgG. Lyt 1+23− T cells are directly triggered to factor production by Fc subfragments, derived from intact Fc fragments by macrophage‐dependent enzymatic cleavage. These factor(s) replace T cell function in two Fc‐mediated immune responses; induction of polyclonal antibody synthesis, and potentiation of anti‐SRBC responses.Keywords
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