The Relative Roles of Vitamins, Protein, and the Salmonellosis Resistance Factor in the Natural Resistance of Mice to Salmonellosis

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Abstract
The results and analysis of this factorial experiment can be summarized in the following set of statements, each of which can be asserted at the 99% confidence level. In a factorial analysis of the relative roles of the Salmonellosis resistance factor (SRF), protein levels, and vitamin levels in survivorship in mouse salmonellosis, only SRF emerged with certitude as a resistance-promoting factor. At “normal” vitamin levels, increasing dietary protein levels ranging from 5 to 30% affected survivorship frequency linearly, but divergently: increasing survivorship obtained in the presence of SRF and decreasing survivorship in its absence. This two-way, SRF × protein, interaction was obliterated by increasing the vitamin levels tenfold. The consequence was a three-way interaction, SRF × protein × vitamins, the only other significant result to emerge from the factorial experiment.