EFFECTIVENESS OF A NEW COMPOUND, BENEMID, IN ELEVATING SERUM PENICILLIN CONCENTRATIONS

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Abstract
The effect of the oral administration of 0.5 gin. of Benemid every 6 hrs. on serum penicillin levels was measured in 74 patients. In 51 patients treated with procaine penicillin, there was enhancement of penicillin levels following Benemid in 81% with an average fold increase of 2.87. In 23 patients treated with crystalline penicillin the levels were higher in 96%, with an average fold increase of 5.10. This 3- to 5-fold enhancement of penicillin levels should make the therapy of certain penicillin resistant infections considerably less expensive, and simpler from a mechanical standpoint.