VARIATION IN CONTRACTILE RESPONSE CHARACTERISTICS OF RABBIT AORTA STRIPS WITH SURFACE OF DRUG ENTRY
- 1 January 1979
- journal article
- research article
- Vol. 210 (1) , 51-55
Abstract
Contractile responses of rabbit aorta strips to norepinephrine in the presence of cocaine, histamine and serotonin entering through the intima were compared with those when these drugs enter via the adventitia. The responses to entry through the inner compared with the outer surface occur after a shorter latency, rise at a greater initial velocity and reach a high steady state. Differences persist after removal of the tunica adventitia. Responses of strips to intimal entry appear identical to those of the intact strip. The results suggest an asymmetry of vascular smooth muscle cell characteristics across the thickness of the tunica media of the rabbit thoracic aorta.This publication has 5 references indexed in Scilit:
- Action of sympathetic nerves of inner and outer muscle of sheep carotid artery, and effect of pressure on nerve distribution.The Journal of Physiology, 1976
- Evidence for α-Adrenergic Receptors on Intimal EndotheliumJournal of Vascular Research, 1975
- CONCERNING DISTRIBUTION OF ENDOGENOUS NOREPINEPHRINE IN ADVENTITIAL AND MEDIA-INTIMAL LAYERS OF RABBIT AORTA AND CAPACITY OF THESE LAYERS TO BIND TRITIATED NOREPINEPHRINE1968
- SYMPATHETIC NERVE-FREE VASCULAR MUSCLE1967
- THE PHARMACOLOGY OF VASCULAR SMOOTH MUSCLE1955