Pharmacokinetics of phenoxymethyl penicillin (penicillin V) in calves

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Abstract
Phenoxymethyl penicillin (penicillin V) was administered intravenously (i.v.) and orally to pre-ruminant calves and the distribution and elimination kinetics, as well as the oralbioavailability, were determined. After i.v. injection, the drug was distributed rapidly in the body, the elimination half-life (t1/2.beta.) was 34 min and the apparent volume of distribution at steady-state (Vd/ss) was 0.30 l/kg. Mean peak serum drug concentrations were directly related to the oral dose administered, i.e. 0.22 .mu.g/ml, 1.06 .mu./ml and 2.14 .mu.g/ml after dosing at 10, 20 and 40 mg/kg, respectively. The elimination t1/2 of the drug after oral dosing varied between 90 and 110 min, and the oral bioavailability was approximately 30% of the dose. The co-administration of phenoxymethyl penicillin and probenecid resulted in elevation and prolongation of serum drug concentration. The percentage of drug bound to serum proteins was 78.8% .+-. 8.2%. Phenoxymethyl penicillin was probably inactivated and degraded in the gatrointestinal tract of 6-week-old calves fed exclusively hay, silage and concentrates as very low and erratic serum drug concentrations were measured after these calves were dosed orally with the drug at 40 mg/kg. In view of the narrow antibacterial spectrum of the drug and the relatively high dose required, it appears that phenoxymethyl penicillin can only be of limited practical value for the treatment of bacterial infections in preruminant calves.