Antibiotic susceptibilities of human isolates of Pasteurella multocida

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Abstract
Seventeen human strains of P. multocida, biochemically similar to, if not identical with, isolates of animal origins, were tested for susceptibility to 16 antimicrobial agents utilizing a microtiter broth dilution technique. Ten isolates were also tested against 11 antibiotics by disk diffusion. The most active drugs with respect to median minimal inhibitory concentration (mg/ml) were tetracycline (0.09), penicillin G (0.78), ampicillin (0.78), carbenicillin (1.56), cephalothin (1.56) and chloramphenicol (1.56). With the exception of tetracycline, median minimal inhibitory concentration and minimal bactericidal concentration values were equal or differed by no more than a factor of 2. Semisynthetic penicillins, clindamycin, erythromycin and aminoglycosides had relatively low activities, suggesting that these agents would be poor choices for P. multocida infection treatment.