Effect of surfactants on transmucosal fluid movement and drug absorption from rat small intestine.

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Abstract
Effects of surfactants on salicylamide absorption was investigated from the view point of the transmucosal fluid movement using the regular in situ recirculation perfusion technique with the rat small intestine. Surfactants used were polysorbate 80, Pluronic F 68 and Pluronic L 64, and they were dissolved in perfusates in appropriate concentrations. To obtain an accurate ratio of the fluid movement in the presence of surfactants, the cylinder method was developed, and validity of the method was demonstrated. Based on the results obtained concerning the effect of surfactants on the drug absorption, the effect of the surfactant on the transmucosal fluid movement was apparently demonstrated. Since extent of the affection was unnegligible, it was suggested that the factor of the transmucosal fluid movement should be taken into consideration as well as the effect of the entrapment of the drug in micelle of the surfactant when the effect of the surfactant on drug absorption would be studied. The mode of the affection was different from those brought about by osmotical change, and the surfactant inhibited only in the process of fluid absorption. Based on the difference in nature, the water-molecule-holding effect of the surfactant was considered and discussed.