INCREASE OF IGA-BEARING PERIPHERAL-BLOOD LYMPHOCYTES IN CHILDREN WITH HENOCH-SCHOENLEIN PURPURA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 64  (6) , 918-922
Abstract
Aberration of Ig[immunoglobulin]A-bearing peripheral blood lymphocytes in children with Henoch-Schoenlein purpura was investigated. A marked increase of IgA-bearing lymphocytes in peripheral blood during the acute phase of Henoch-Schoenlein was demonstrated in 18 children. The levels of IgA-bearing lymphocytes returned to the normal levels after the acute symptoms of Henoch-Schoenlein purpura subsided. In patients who developed purpura nephritis, the increased levels of IgA-bearing lymphocytes in peripheral blood were retained after the disappearance of purpura and lasted for more than 12 mo. The monitoring of IgA-bearing peripheral blood lymphocytes was useful for the screening of patients with Henoch-Schoenlein purpura and purpura nephritis.