How Arachidonic Acid Depresses Thymus Weight
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 59 (4) , 432-436
- https://doi.org/10.1159/000232291
Abstract
Subcutaneous injection of arachidonic acid depresses thymus weight. This is unlikely to be a stress effect, since arachidonic acid is equally active in adrenalectomised animals. Amongst other fatty acids tested, those capable of being metabolised to arachidonic acid have greater thymolytic activity than those which are not arachidonic acid precursors. Thymolysis is significantly inhibited by indomethacin, a drug which blocks the conversion of arachidonic acid to prostaglandins.Keywords
This publication has 2 references indexed in Scilit:
- Prostaglandins and the immune responseLife Sciences, 1977
- Importance of the Spleen for the Immuno-Inhibitory Action of Linoleic Acid in MiceInternational Archives of Allergy and Immunology, 1977