CLINICAL SIGNIFICANCE OF SENILE CARDIAC AMYLOIDOSIS - PROSPECTIVE CLINICOPATHOLOGICAL STUDY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 46  (183) , 381-387
Abstract
The heart was screened for amyloid deposits in an unselected post-mortem series of 244 patients over 60. Cardiac amyloidosis was found in 121 cases (49.6%), but was limited to minor atrial involvement in 55 (22.5%). The prevalence and severity of cardiac amyloidosis were significantly related to age and sex, females having the higher prevalence (56% compared with 37 1/2%). Cardiac amyloidosis was significantly correlated with the occurrence of atrial fibrillation and cardiac failure during the period of admission to hospital. Cardiac amyloidosis showed no significant correlations with other factors including ECG evidence of left ventricular hypertrophy, ischemia and bundle branch block, pathological evidence of cardiac enlargement or ischemia, diagnosis of malignant disease, generalized wasting and the occurrence of digitalis toxicity.

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