Fuchs' heterochromic uveitis: A reappraisal of the clinical spectrum

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Abstract
The varying clinical appearance within a group of 103 patients with Fuchs' Heterochromic Uveitis (FHU) is discussed. Bilateral cases accounted for 7.8% of patients. Cataract was found in 80.2% of cases after 8.8 years mean follow-up, and glaucoma affected 26.2% of patients. The most important diagnostic criteria are the typical pattern of iris atrophy and depigmentation, the characteristic intraocular inflammation, and complicated cataract. These are described in detail. The correct diagnosis of FHU is important because it affects future management and prognosis. The presence or absence of macroscopic heterochromia is not a helpful component of the ocular examination and should play little part in diagnosis. FHU does not necessarily present in its classical form, and may first resemble acute anterior uveitis or pars planitis. The syndrome may be the end stage of a number of different conditions.