Activity of OPT-80, a Novel Macrocycle, Compared with Those of Eight Other Agents against Selected Anaerobic Species

Open Access

1 November 2004

journal article
research article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 48 (11) , 4430-4434
https://doi.org/10.1128/aac.48.11.4430-4434.2004

Abstract

Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile ), with MICs ranging between ≤0.016 and 0.25 μg/ml.

Keywords

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